But those who, out of envy, disregard these teachings and do not follow them regularly are to be considered bereft of all knowledge, befooled, and ruined in their endeavors for perfection.

PURPORT

The flaw of not being Krsna conscious is clearly stated herein. As there is punishment for disobedience to the order of the supreme executive head, so there is certainly punishment for disobedience to the order of the Supreme Personality of Godhead. A disobedient person, however great he may be, is ignorant of his own self, and of the Supreme Brahman, Paramatma and the
Personality of Godhead, due to a vacant heart. Therefore there is no hope of perfection of life for him.

>>> Ref. VedaBase => Bg 3.32