When Krsna left Vrndavana for Mathura, the gopis became most dejected and spent the rest of their lives simply crying in separation from Krsna. This means that in one sense they were never actually separated from Krsna. There is no difference between thinking of Krsna and associating with Him. Rather, vipralambha-seva, thinking of Krsna in separation, as Sri Caitanya Mahaprabhu did, is far better than serving Krsna directly.

Srila Prabhupada, The Nectar of Instruction, Text 10 Purport