Caitanya Mahaprabhu and Nityananda Prabhu drive away the five kinds of ignorance of the conditioned souls. In the Mahabharata, Udyoga-parva, Forty-third Chapter, these five kinds of ignorance are described. They are (1) accepting the body to be the self, (2) making material sense gratification one’s standard of enjoyment, (3) being anxious due to material identification, (4) lamenting and (5) thinking that there is anything beyond the Absolute Truth.

Srila Prabhupada CC Adi 1.102 ppt