Unless we cooperate with the Supreme Lord, our life is baffled. I have given the example many times that a screw which has fallen from a machine has no value. But when the same screw is again attached to the machine, it has value. Similarly, we are part and parcel of God. So without God, what is our value? No value! We should again come back to our position of attachment to God. Then we have value.

Srila Prabhupada, in PQPA ch 5: Becoming Pure